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Taurohyodeoxycholic acid sodium salt

CAS No. 110026-03-4

Taurohyodeoxycholic acid sodium salt( Taurodeoxychloic Acid sodium hydrate | Sodium taurodeoxycholate monohydrate )

Catalog No. M21204 CAS No. 110026-03-4

Taurohyodeoxycholic acid sodium salt a hydrophilic bile salt on bile salt and biliary lipid secretion in the rat.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Taurohyodeoxycholic acid sodium salt
  • Note
    Research use only, not for human use.
  • Brief Description
    Taurohyodeoxycholic acid sodium salt a hydrophilic bile salt on bile salt and biliary lipid secretion in the rat.
  • Description
    Taurohyodeoxycholic acid sodium salt a hydrophilic bile salt on bile salt and biliary lipid secretion in the rat.
  • In Vitro
    Cell Proliferation Assay Cell Line:IEC-6 and caco-2 cells Concentration:0, 0.05, 0.50, and 1.00 mM Incubation Time:1, 2, 4 and 6 days Result:Significantly stimulated intestinal epithelial cell proliferation in a dose-dependent manner. Cell Cycle Analysis Cell Line:IEC-6 cells Concentration:0, 0.05, 0.50, and 1.00 mM Incubation Time:24 hResult:Significantly increased cells in S phase and decreased cells in G1-phase.Western Blot Analysis Cell Line:IEC-6 cells Concentration:0.5 mM Incubation Time:1 and 6 days Result:Significantly increased c-myc protein expression.
  • In Vivo
    Animal Model:C57BL/6N mice, Lipopolysaccharides (HY-D1056) injection model of sepsis Dosage:0.5 mg/kg Administration:Intravenous injection, 30 min or 24 h after LPS injection Result:Improved the survival rate of mice with sepsis. Decreased liver and kidney damage in septic mice. Ameliorated systemic inflammation and normalized blood pressure in septic mice.
  • Synonyms
    Taurodeoxychloic Acid sodium hydrate | Sodium taurodeoxycholate monohydrate
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Caspase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    110026-03-4
  • Formula Weight
    540.71
  • Molecular Formula
    C26H47NNaO7S+
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (231.18 mM)
  • SMILES
    C[C@H](CCC(=O)NCCS(=O)(=O)[O-])[C@H]1CC[C@@H]2[C@]1(CC[C@H]3[C@H]2C[C@@H]([C@H]4[C@@]3(CC[C@H](C4)O)C)O)C.[Na+]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Angelico M Baiocchi L Nistri A et al. Effect of taurohyodeoxycholic acid a hydrophilic bile salt on bile salt and biliary lipid secretion in the rat[J]. Digestive Diseases & Sciences 1994 39(11):2389-2397.
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